.
Sumatriptan is a member of the selective serotonin receptor agonist family of drugs used to treat, but not prevent, migraine headaches. Sumatriptan is available in injection, nasal spray, and oral tablet forms.
Interactions with Dietary Supplements
5-Hydroxytryptophan (5-HTP) and
L-tryptophan
Sumatriptan works by stimulating serotonin receptors in the brain. 5-HTP and L-tryptophan are
converted to serotonin in the brain, and taking them with sumatriptan could increase
sumatriptan-induced side effects. However, no interactions have yet been reported with
sumatriptan and 5-HTP or L-tryptophan.
Interactions with Foods and Other Compounds
Food
Sumatriptan tablets may begin to work faster when taken with fluid on an empty stomach at the
first sign of migraine.1 2
Summary of Interactions for Sumatriptan
| Depletion or interference | None known |
|---|---|
| Adverse interaction | 5-Hydroxytryptophan
(5-HTP)* L-tryptophan* |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Threlkeld DS, ed. Central Nervous System Drugs, Agents for Migraine, Serotonin 5-HT1 Receptor Agonists. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1996, 256a.
2. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 253.
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