.
Sucralfate is used to treat intestinal ulcers, and it is a type of drug known as a polysaccharide antipeptic.
Interactions with Dietary Supplements
Calcium
Slight increases in blood calcium levels may occur in people taking sucralfate, which could be
aggravated by calcium supplementation.1 Therefore, people taking calcium
supplements and sucralfate should have their blood calcium levels monitored by their
healthcare practitioner and may need to avoid calcium supplementation.
Phosphorus
People taking sucralfate may develop lower than normal blood levels of phosphorus.2
A 42-year-old woman who took sucralfate for two weeks experienced bone pain that was caused by
low phosphorus levels. The bone pain disappeared after she stopped taking the drug and began
supplementing with phosphorus.3 Individuals taking sucralfate should have their
blood phosphorus levels monitored regularly by their healthcare practitioner and may need to
take supplemental phosphorus.
Summary of Interactions for Sucralfate
| Depletion or interference | Calcium Phosphorus |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Vucelic B, Hadzic N, Gragas J, Puretic Z. Changes in serum phosphorus, calcium, and alkaline phosphatase due to sucralfate. Int J Clin Pharmacol Ther Toxicol 1986;24:93–6.
2. Vucelic B, Hadzic N, Gragas J, Puretic Z. Changes in serum phosphorus, calcium, and alkaline phosphatase due to sucralfate. Int J Clin Pharmacol Ther Toxicol 1986;24:93–6.
3. Chines A, Pacifici R. Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature. Calcif Tissue Int 1990;47:291–5.
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