.
Risedronate is used to treat Paget’s disease of the bone, and is in a family of drugs known as bisphosphonates.
Interactions with Dietary Supplements
Calcium and Vitamin D
Short-term treatment with risedronate in people with hyperparathydoidism—a disorder
characterized by high blood levels of calcium—resulted in lower calcium blood
levels.1 Additional research is needed to determine whether people taking
risedronate for Paget’s disease might develop low blood calcium levels. As a precaution,
people with Paget’s disease should take supplemental calcium and vitamin D if dietary
intake is inadequate. However, taking risedronate at the same time as calcium supplements
reduces absorption of the drug.2 Therefore, people taking risedronate for
Paget’s disease should take calcium supplements an hour before or two hours after taking
the drug.
Minerals
Taking risedronate at the same time as iron, zinc, or magnesium may reduce the
amount of drug absorbed.3 Therefore, people taking risedronate who wish to
supplement with these minerals should take them an hour before or two hours after the
drug.
Interactions with Foods and Other Compounds
Antacids
Taking risedronate at the same time as antacids containing
calcium or magnesium may reduce absorption of the
drug. Therefore, people taking risedronate should take calcium- or magnesium-containing
antacids an hour before or two hours after the drug.
Food
One controlled study showed that taking risedronate either a half an hour before or two hours
after a meal dramatically reduced absorption of the drug, compared with taking the drug one
hour before or four hours after a meal.4 Consequently, people should take
risedronate one hour before a meal or 4 hours after a meal, as long as the latter is at least
one hour before the next meal.
Summary of Interactions for Risedronate
| Depletion or interference | Calcium* |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | Antacids Calcium Food Iron Magnesium Zinc (absorption) Zinc (action) |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Reasner CA, Stone MD, Hosking DJ, et al. Acute changes in calcium homeostasis during treatment of primary hyperparathyroidism with risedronate. J Clin Endocrinol Metab 1993;77:1067–71.
2. Sifton DW, ed. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504–6.
3. Sifton DW, ed. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc. 2000, 2504–6.
4. Mitchell DY, Heise MA, Pallone KA, et al. The effect of dosing regimen on the pharmacokinetics of risedronate. Br J Clin Pharmacol 1999;48:536–42.
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The information presented in VitaminLore is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.