.
Pentoxifylline decreases blood thickness and improves red blood cell flexibility. Pentoxifylline is used to improve symptoms of intermittent claudication and in the treatment of other circulatory disorders.
Interactions with Dietary Supplements
Vitamin E
The combination of vitamin E and pentoxifylline has been used successfully to reduce damage to
normal tissues caused by radiation therapy.1
Summary of Interactions for Pentoxifylline
| Depletion or interference | None known |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | Vitamin E |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Delanian S, Balla-Mekias S, Lefaix JL. Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. J Clin Oncol 1999;17:3283–90.
2. Threlkeld DS, ed. Blood Modifiers, Hemorheologic Agent, Pentoxifylline. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1997, 89f–9g.
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