.
Mirtazapine is used to treat people with mental depression, especially those who are also nervous and have trouble sleeping. It is in a class of drugs called tetracyclic antidepressants.
Interactions with Dietary Supplements
Melatonin
Taking mirtazapine results in enhanced secretion of melatonin at night;1 this may
explain part of the mechanism of the effects of mirtazapine. Controlled research is needed to
determine whether melatonin supplementation might enhance either the beneficial or the adverse
effects of mirtazapine.
Interactions with Foods and Other Compounds
Alcohol
Drinking alcoholic beverages while taking mirtazapine may enhance the effects of the drug,
including impairment of thinking, judgment, and performance of difficult tasks; therefore, it
should be avoided.2
Summary of Interactions for Mirtazapine
| Depletion or interference | None known |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
| Other (see text) | Melatonin* |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Palazidou E, Papadopoulos A, Sitsen A, et al. An alpha 2 adenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man. Psychopharmacology (Berl) 1989;97:115–7.
2. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2109–11.
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