.
Mesalamine is used to treat mildly to moderately active ulcerative colitis and to prevent recurrence.
Interactions with Herbs
Psyllium (Plantago
ovata)
Taking 20 grams of psyllium seeds together with mesalamine for 12 months was more effective at
maintaining remission of ulcerative colitis than taking either the drug or herb
alone.1 People taking mesalamine should consult with their healthcare practitioner
to determine whether they should add psyllium seeds to their treat regimen.
Summary of Interactions for Mesalamine
| Depletion or interference | None known |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | Psyllium |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Fernandez-Banares F, Hinojosa J, Sanchez-Lombrana JL, et al. Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn’s disease and Ulcerative Colitis (GETECCU). Am J Gastroenterol 1999;94:427–33.
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