.
This is a combination drug containing two ingredients, diphenoxylate and atropine, that is used in the treatment of diarrhea. Diphenoxylate is in a class of drugs known as antidiarrheals.
Interactions with Herbs
Tannin-containing herbs
Tannins are a group of unrelated chemicals that give plants an astringent taste. Herbs
containing high amounts of tannins, such as green
tea (Camellia sinensis), black tea, uva
ursi (Arctostaphylos uva-ursi), black walnut (Juglans nigra),red raspberry (Rubus idaeus),oak (Quercus spp.), and
witch hazel (Hamamelis virginiana), may interfere with the absorption of the
drug when taken by mouth.1
Interactions with Foods and Other Compounds
Alcohol
Diphenoxylate may enhance the actions of alcohol,2 resulting in increased
drowsiness, dizziness, imbalance, and poor response times. Therefore, people taking
diphenoxylate should avoid alcohol, especially when staying alert is necessary.
Summary of Interactions for Lomotil, Lonox
| Depletion or interference | None known |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | Tannin-containing herbs* such as green tea, black tea, uva ursi, black walnut, red raspberry, oak, and witch hazel |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Institute, 1997, 100.
2. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2923–4.
Copyright © 2002 VitaminLore, Inc. All rights reserved. www.VitaminLore.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Click here Buy Vitamins and Nutritional Supplements at very low prices..
Buy Brand name Vitamins for less from www.vitaminlore.com. Safetychecker.
The information presented in VitaminLore is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.