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Ketoprofen

Also indexed as: Orudis®, Oruvail®

Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is in a class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs).

Interactions with Dietary Supplements

Lithium
Lithium is a mineral that may be present in some supplements and is also used in large amounts to treat mood disorders such as manic-depression. Research has shown that non-steroidal anti-inflammatory drugs may increase blood levels of lithium,1 resulting in side effects such as diarrhea, nausea, muscle weakness, and lack of coordination. Though there is no research available to show that ketoprofen increases lithium blood levels, until more information is available, people taking ketoprofen should talk with their healthcare practitioner before supplementing with lithium.

Interactions with Herbs

Willow (Salix alba)
Willow bark contains salicin, which is related to aspirin. Both salicin and aspirin produce anti-inflammatory effects after they have been converted to salicylic acid in the body. The interaction between salicylic acid and ketoprofen is complex. While it may enhance the effectiveness of ketoprofen, salicylic acid also speeds its elimination from the body.2 Consequently, people taking ketoprofen should avoid herbal products that contain willow bark.

Interactions with Foods and Other Compounds

Food
Ketoprofen may cause stomach upset and should therefore be taken with food.3

Calories and Fat
Taking a slow-release form of ketoprofen with low-fat, low-calorie food may increase the absorption of the drug, compared with taking it with a high-fat, high-calorie meal.4 Individuals who eat a diet high in calories and fat may require an adjustment in the daily amount of ketoprofen taken or may experience greater benefit by switching to a low-fat, low-calorie diet. Consult a qualified professional about matching ketoprofen dosage with dietary fat and calorie intake.

Summary of Interactions for Ketoprofen

Depletion or interference Lithium*
Adverse interaction Lithium*
White willow*
Side effect reduction/prevention None known
Supportive interaction None known
Reduced drug absorption/bioavailability Willow*

For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

References:

1. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 3285–8.

2. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 3285–8.

3. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 3285–8.

4. Le Liboux A, Teule M, Frydman A, et al. Effect of diet on the single- and multiple-dose pharmacokinetics of sustained-release ketoprofen. Eur J Clin Pharmacol 1994;47:361–6.