.
Combination drug: Combivent®
Ipratropium bromide is a drug used by oral inhalation to keep breathing passages open in chronic obstructive pulmonary diseases, including chronic bronchitis and emphysema. Ipratropium bromide for oral inhalation is available alone and in a combination product. It is also available as a nasal spray to relieve runny nose associated with allergies and common colds.
Interactions with Foods and Other Compounds
Food
Atrovent® and Combivent® for oral inhalation contain soy lecithin. Rarely, people very sensitive to
soy have reacted to these drugs,1 and life-threatening anaphylactic reaction is
possible, though extremely rare. Ipratropium bromide nasal spray and solution for inhalation
contain no soy lecithin.
Summary of Interactions for Ipratropium Bromide
| Depletion or interference | None known |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
| Other (see text) | Soy |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Threlkeld DS, ed. Respiratory Drugs, Respiratory Inhalant Products, Anticholinergics, Ipratropium Bromide. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1996, 182f–2g.
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