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Glyburide

Also indexed as: Diabeta®, Glibenclamide, Glynase Prestab®, Glynase™, Micronase®, Pres Tab®

Glyburide is a sulfonylurea drug used to lower blood sugar levels in people with type 2 (non-insulin-dependent) diabetes. Maintaining normal blood sugar levels helps reduce health problems associated with diabetes. People with diabetes should consult with their doctor before starting or stopping any form of treatment including drug therapy, herbal products, supplements, and others.

Consumption of a high-fiber diet and/or supplementation with nutrients such as chromium, biotin, vitamin E, and others or herbs such as Gymnema sylvestre will often improve blood-sugar control in diabetics. In such cases, the amount of blood sugar-lowering drugs may need to be reduced in order to avoid a hypoglycemic reaction. Anyone taking medication for diabetes should consult the prescribing physician before making dietary changes or taking nutrients or herbs that are designed to lower blood-sugar levels.

Interactions with Herbs

Aloe (Aloe vera)
One single-blind study in Thailand reported that combining 1 tablespoon of aloe juice twice daily with glyburide significantly improved blood sugar and lipid levels in people with diabetes, compared with placebo.1 Previously, glyburide by itself had not effectively controlled the diabetes in the people in this study.

Interactions with Foods and Other Compounds

Food
Glyburide may be taken with food to avoid gastrointestinal (GI) upset.2 Effective treatment of type 2 diabetes with glyburide includes adherence to recommended dietary guidelines.

Alcohol
Alcohol consumption may interfere with blood-sugar control during glyburide therapy.3 Alcohol may interact with glyburide, causing facial flushing, headache, light-headedness, nausea, breathlessness, and other symptoms.4 People taking glyburide should avoid alcohol.

Summary of Interactions for Glyburide

Depletion or interference None known
Adverse interaction Chromium*
Side effect reduction/prevention None known
Supportive interaction Aloe vera*
Reduced drug absorption/bioavailability None known
Other (see text) Biotin
Gymnema
Vitamin E

For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

References:

1. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed 1996;3:245–8.

2. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.

3. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.

4. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.