.
Cycloserine is a broad-spectrum antibiotic used to treat tuberculosis. It is used rarely for treating noninfectious diseases.
Interactions with Dietary Supplements
Calcium and Magnesium
Cycloserine may interfere with calcium and magnesium absorption.1 The clinical
significance of these interactions is unclear.
Folic acid, Vitamin B6, Vitamin
B12
Cycloserine may interfere with the absorption and/or activity of folic acid, vitamin B6, and
vitamin B12.2 3 The clinical importance of this interaction is
unclear.
Vitamin K
Many antibiotics taken by mouth, including cycloserine, may kill friendly bacteria in the
large intestine that produce vitamin K.4 With short-term (a few weeks or less)
antibiotic use, the actions on vitamin K are usually mild and cause no problems. After
antibiotic therapy is completed, vitamin K activity returns to normal.
Interactions with Foods and Other Compounds
Alcohol
Cycloserine may cause drowsiness.5 Alcohol may intensify this drowsiness and
increase the risk of accidents during activities requiring alertness. Seizures are a possible
side effect of cycloserine therapy. Alcohol consumed during cycloserine therapy may increase
the risk of seizures.6 People should avoid alcohol-containing products during
cycloserine therapy.
Summary of Interactions for Cycloserine
| Depletion or interference | Calcium* Folic acid* Magnesium* Vitamin B12* Vitamin B6* Vitamin K |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.
2. Roe D, Campbell T, eds. Drugs and Nutrients: The Interactive Effects. New York: Marcel Decker, 1984, 288–9, 505–23.
3. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.
4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 86.
5. Threlkeld DS, ed. Anti-Infectives, Antituberculosis Drugs, Cycloserine. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1990, 394–5.
6. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 85.
Copyright © 2002 VitaminLore, Inc. All rights reserved. www.VitaminLore.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Click here Buy Vitamins and Nutritional Supplements at very low prices..
Buy Brand name Vitamins for less from www.vitaminlore.com. Safetychecker.
The information presented in VitaminLore is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.