.
Clofibrate is a drug used to lower cholesterol in people with high blood cholesterol. It is rarely used, due to the possibility of liver damage and the availability of safer, more effective drugs.
Interactions with Dietary Supplements
Vitamin B12
Clofibrate has been reported to reduce absorption of vitamin B12.1
Interactions with Herbs
Milk thistle
(Silibum marianum)
Although there have been no clinical studies, use of milk thistle with clofibrate may
theoretically lower the risk of liver side effects associated with the drug. People may take a
standardized milk thistle extract supplying 70–80% silymarin at an amount of 200 mg
three times per day.
Summary of Interactions for Clofibrate
| Depletion or interference | Vitamin B12* |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | Milk thistle* |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Robinson C, Weigly E. Basic Nutrition and Diet Therapy. New York: Macmillan, 1984, 46–54.
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