.
Bupropion is used to treat people with depression and to aid in smoking cessation treatment.
Interactions with Herbs
Yohimbine
A 50-year-old woman who was unresponsive to traditional antidepressant therapy was reported to
have a marked and persistent improvement in mood when yohimbine was added to her bupropion
therapy.1 Further research is necessary to determine the significance of this
finding.
Interactions with Foods and Other Compounds
Alcohol
Unlike most other antidepressant drugs, there is no evidence that alcohol causes significant
changes in blood levels of bupropion.2 However, people taking bupropion who are
also attempting to discontinue chronic alcohol consumption have been reported to sometimes
experience convulsions.3
Summary of Interactions for Bupropion
| Depletion or interference | None known |
|---|---|
| Adverse interaction | Alcohol |
| Side effect reduction/prevention | None known |
| Supportive interaction | Yohimbine* |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Pollack MH, Hamerness P. Adjunctive yohimbine for treatment in refractory depression. Biol Psychiatry 1993;33:220–1.
2. Posner J, Bye A, Jeal S, et al. Alcohol and bupropion pharmacokinetics in healthy male volunteers. Eur J Clin Pharmacol 1984;26:627–30.
3. Storrow AB. Bupropion overdose and seizure. Am J Emerg Med 1994;12:183–4.
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The information presented in VitaminLore is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.