.
Combination drugs: Monozide®, Ziac®
Bisoprolol is a beta-blocker drug used to lower blood pressure in people with hypertension.
Interactions with Dietary Supplements
Potassium
Some beta-adrenergic blockers (called “nonselective” beta blockers) decrease the
uptake of potassium from the blood into the cells,1 leading to excess potassium in
the blood, a potentially dangerous condition known as hyperkalemia.2 People taking
beta-blockers should therefore avoid taking potassium supplements, or eating large quantities
of fruit (e.g.,
bananas), unless directed to do so by their doctor.
Interactions with Herbs
Pleurisy root
As pleurisy root and other plants in the Aesclepius species contain cardiac
glycosides, it is best to avoid use of pleurisy root with heart medications such as
bisoprolol.3
Interactions with Foods and Other Compounds
Food
Bisoprolol may be taken with or without food.4
Alcohol
Bisoprolol may cause drowsiness, dizziness, lightheadedness, or blurred vision.5
Alcohol may intensify these effects and increase the risk of accidental injury. To prevent
problems, people taking bisoprolol should avoid alcohol.
Summary of Interactions for Bisoprolol
| Depletion or interference | None known |
|---|---|
| Adverse interaction | High-potassium foods* Pleurisy root Potassium supplements* |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med 1980;302:431–4.
2. Lundborg P. The effect of adrenergic blockade on potassium concentrations in different conditions. Acta Med Scand Suppl 1983;672:121–6 [review].
3. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.
4. Leopold G, Pabst J, Ungethum W, Buhring KU. Basic pharmacokinetics of bisoprolol, a new highly beta 1-selective adrenoceptor antagonist. J Clin Pharmacol 1986;26:616–21.
5. Threlkeld DS, ed. Diuretics and Cardiovasculars, Beta-Adrenergic Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1993, 158o.
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The information presented in VitaminLore is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.