.
Bisacodyl, a stimulant-type laxative used to treat constipation, is available as a nonprescription product. All laxatives, including bisacodyl, should be used for a maximum of one week to prevent laxative dependence and loss of normal bowel function.
Interactions with Dietary Supplements
Potassium and other
nutrients
Prolonged and frequent use of stimulant laxatives, including bisacodyl, may cause excessive
and unwanted loss of water, potassium, and other nutrients from the body.1
2 Bisacodyl should be used for a maximum of one week, or as directed on the package
label. Excessive use of any laxative can cause depletion of many nutrients. In order to
protect against multiple nutrient deficiencies, it is important to not overuse
laxatives.3 People with constipation should consult with their doctor or pharmacist
before using bisacodyl.
Interactions with Foods and Other Compounds
Food
Bisacodyl tablets are enteric coated to pass through the stomach and dissolve in the small
intestine. Milk, dairy products, vegetables, almonds, chestnuts, and other foods can cause the
enteric coating to dissolve in the stomach, leading to irritation and cramping.4
People should take bisacodyl one hour before or two hours after meals to avoid this
problem.
Summary of Interactions for Bisacodyl
| Depletion or interference | Potassium |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Fleming BJ, Genuth SM, Gould AB, Kaminokowski MD. Laxative induced hypokalemia, sodium depletion, and hyperreninemia. Effects of potassium and sodium replacement on the rennin angiotensin system. Ann Intern Med 1975;83:60–2.
2. Threlkeld DS, ed. Gastrointestinal Drugs, Laxatives. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1991, 319a.
3. Threlkeld DS, ed. Gastrointestinal Drugs, Laxatives. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1991, 319a.
4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 49.
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