.
Anthralin is a drug applied only to affected skin areas to treat psoriasis.
Interactions with Dietary Supplements
Vitamin E
Anthralin can cause inflammation of the skin. A preliminary study found that topical use of
vitamin E was able to protect against this side effect.1 This report used a
tocopherol form of the vitamin rather than tocopheryl. This makes sense, as there is no
conclusive proof that the tocopheryl forms (which require an enzyme to split vitamin E from
the fatty acid to which it is attached) have any activity on the skin.
Summary of Interactions for Anthralin
| Depletion or interference | None known |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | Vitamin E (topical) |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Finnen MJ, Lawrence CM, Shuster S. Inhibition of dithranol inflammation by free-radical scavengers. Lancet 1984;ii:1129–30.
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