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Amphotericin B

Also indexed as: Fungizone®

Amphotericin B is an antifungal drug. Topically, it is used to treat skin yeast infections. Intravenously, it is used to treat a variety of life-threatening fungal infections.

Interactions with Dietary Supplements

Magnesium
Amphotericin B has been reported to increase urinary excretion of magnesium.1 It remains unclear whether it is important for people taking this drug to supplement magnesium.

Summary of Interactions for Amphotericin B

Depletion or interference Magnesium*
Adverse interaction None known
Side effect reduction/prevention None known
Supportive interaction None known
Reduced drug absorption/bioavailability None known

For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

References:

1. McLean R. Magnesium and its therapeutic uses: A review. Am J Med 1994;96: 63–76.